Specific chromatin immunoprecipitation of salt-fractionated infected cell extracts has demonstrated that the CCCTC-binding factor (CTCF), a highly conserved, 11-zinc-finger DNA-binding protein with known roles in cellular and viral ranchy doodle genome organization and gene expression, specifically binds the genome of Minute Virus of Mice (MVM).Mut
BACKGROUND Chronic cardiomyopathy occurs in 20-40% of the patients with Chagas disease.Autoimmune mechanisms may contribute to its pathogenesis.We diagnosed several cases of systemic autoimmune diseases among Bolivian migrants in Geneva with a high prevalence of Chagas disease.OBJECTIVES We tested the hypothesis of a clinical association between sy
Mitochondrial DNA (mtDNA) has been one of the most extensively studied molecules in ecological, evolutionary and clinical genetics.In its early application in evolutionary genetics, mtDNA was assumed to be a selectively neutral marker conferring negligible fitness consequences for its host.However, this dogma has been overturned in recent years due